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CASE REPORT
Year : 2016  |  Volume : 43  |  Issue : 3  |  Page : 155-157

Vitamin D-dependent rickets type 2: Alopecia responding to 1,25 hydroxy Vitamin D


Department of Pediatrics, Jawaharlal Nehru Medical College, Belagavi, Karnataka, India

Correspondence Address:
Prithi R Inamdar
A14/2 , Jawaharlal Nehru Medical College (JNMC) Quarters, Nehru Nagar, Belagavi - 590 010, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-5009.190548

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Vitamin D-dependent type two rickets (VDDRII) is a rare autosomal recessive disorder caused by mutation in the vitamin D receptor gene, leading to end-organ resistance to 1,25(OH) 2 vitamin D3. It presents with refractory rickets and growth retardation presenting in the first year of life. It is frequently associated with alopecia totalis. Due to target organ resistance, its response to vitamin D is poor. The recommended treatment is giving supraphysiological dose of 1,25(OH) 2 vitamin D3 and a high dose of oral or intravenous calcium. The response of alopecia to treatment is generally poor. We present a 3-year-old male child with VDDRII whose alopecia and rickets partially responded to 1,25(OH) 2 vitamin D3.


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