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Year : 2022  |  Volume : 49  |  Issue : 2  |  Page : 121-124

Association of D-dimer and lipid biomarkers with preeclampsia and their role in prediction from a rural tertiary care setting

Department of Physiology, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India

Correspondence Address:
K Jhansi
PhD Scholar, Department of Physiology, Smt. BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jss.jss_52_22

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Background: Preeclampsia affects 5%–7% of all pregnancies globally and is the leading cause of maternal and fetal death and morbidity. The mechanisms responsible for the pathogenesis of preeclampsia are unclear. Preeclampsia is characterized as hypertension with or without proteinuria after the 20th week of pregnancy and is associated with endothelial dysfunction, systemic vasoconstriction, inflammation, oxidative stress, and intrauterine growth restriction, and multiorgan dysfunction. Materials and Methods: A total of 120 women were divided into two groups: 60 women without PE (control group) and 60 women with PE in a prospective observational case–control study conducted in a rural tertiary care setting in India. This study was done from January 2019 to December 2019, after approval from the local ethical committee. Women with singleton pregnancy either primiparous or multiparous, aged between18 and 40 years were included in both case and control groups. Results: The participants in this study ranged in age from 18 to 38 years old, with an average age of 26.38 ± 4.38 years. The average age of the women in the case group was 26.42 + 3.92 years, while the average age of the women in the control group was 27.38 ± 4.52 years. Most of the patients were between the ages of 31 and 40 (51.67%) years. The mean gestational age in the case group was 26.60 ± 2.19 weeks, while it was 26.73 ± 2.39 weeks in the control group. Conclusion: Early screening of pregnant women for high D-dimer levels and lipid profile can play a significant role in reducing the morbidity and mortality of both mother and fetus.

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