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ORIGINAL ARTICLE
Year : 2022  |  Volume : 49  |  Issue : 3  |  Page : 272-276

Association of SNP rs163550 in IL5RA Gene with Risk of Preeclampsia


1 Department of Biochemistry and Bioinformatics, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India
2 Final year MBBS, Rangaraya Medical College, Srikakulam, Andhra Pradesh, India
3 Department of Obstetrics and Gynecology, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh, India
4 Department of General Medicine, Central Research Laboratory, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh, India
5 Department of Biochemistry, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh, India
6 Department of Medicine, Medical University of Sofia, Sofia, Bulgaria
7 Intern, Konaseema Institute of Medical Sciences and Research Foundation, Amalapuram, Andhra Pradesh, India

Correspondence Address:
Dr. K Vijaya Rachel
Department of Biochemistry and Bioinformatics, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jss.jss_70_22

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Background: Several research have looked at the significance of SNPs in inflammatory mediator genes and their link to preeclamptic pregnancies, but the results have not been conclusive enough to explain why SNPs in inflammatory mediator genes may increase the risk of preeclampsia. The goal of this study is to analyze the IL5RA SNPs in order to learn more about the possible link between preeclampsia and inflammatory genes. Materials and Methods: A total of 304 pregnant participants were a part of this prospective observational case-control study, out of which 152 had preeclampsia, and the other 152 participants had normotensive pregnancies. The “polymerase chain reaction-restriction fragment length polymorphism” method was used to genotype SNP rs163550. Results: The commonness of the IL5RA rs163550G allele has been linked to an increased risk for preeclampsia with P value: 0.0230 and odds ratio: 0.6818 (95% confidence interval: 0.489–0.9505). Conclusion: A prominent association among the IL5RA rs163550 SNP and preeclampsia in comparison to nonpreeclampsia has been observed in the study. The study stands first to report IL5RA Polymorphism association with the pathogenesis of preeclampsia's among the Indian population.


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